INTRACELLULAR OSTEOPONTIN PROTECTS FROM AUTOIMMUNITY-DRIVEN LYMPHOMA DEVELOPMENT INHIBITING TLR9-MYD88-STAT3 SIGNALING

Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling

Abstract Background Autoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies.The matricellular protein osteopontin (OPN) has been linked to SLE pathogenesis, as SLE patients show increased serum levels of OPN and often polymorphisms in its gene.Although widely studied

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Optimization of Si Content to Inhibit Inhomogeneous Deformation in Al-Mg-Si Alloy Fabricated via Twin-Roll Casting

Herein, the effects of Si content on the microstructure evolution of Al-Mg-Si alloys during twin-roll casting (TRC) and subsequent heat treatment were characterized using scanning electron microscopy, emission electron probe micro analysis, electron backscatter diffraction, and transmission choc-aid bandages electron microscopy.The effects of insol

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